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Drug: Acyclovir
Vaccination: Vaccines
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Total 138 results found since Jan 2013.
Neonatal herpes simplex virus infection: From the maternal infection to the child outcome
J Med Virol. 2023 Aug;95(8):e29024. doi: 10.1002/jmv.29024.ABSTRACTThis review examines the recent literature on the management of herpes simplex virus (HSV) infections in neonates. We summarized the three clinical categories of maternal HSV infection during pregnancy (primary first episode, nonprimary first episode, or recurrent episode) and the mechanisms of fetal damage. Considering when the transmission of the infection from the mother to the fetus/newborn occurs, three types of neonatal infection can be distinguished: intrauterine infection (5% of cases), postnatal infection (10% of cases), and perinatal infections (8...
Source: Herpes - August 18, 2023 Category: Infectious Diseases Authors: Domenico Umberto De Rose Sarah Bompard Chiara Maddaloni Iliana Bersani Ludovica Martini Alessandra Santisi Daniela Longo Maria Paola Ronchetti Andrea Dotta Cinzia Auriti Source Type: research
The Utilization and Development of Viral Vectors in Vaccines as a Prophylactic Treatment Against Ebola Virus as an Emerging and Zoonotic Infectious Disease
Mini Rev Med Chem. 2023 Jul 25. doi: 10.2174/1389557523666230725115324. Online ahead of print.ABSTRACTAlongside the prescription of commonly used antivirals, such as acyclovir, remdesivir, oseltamivir, and ciprofloxacin, the most efficient way to prevent or treat communicable diseases is by vaccination. Vaccines have been the most efficient way to prevent or treat highly transmissible infectious agents, such as Ebola, Anthrax, and Dengue Fever. Most epidemics of these highly transmissible infectious agents occur in places, such as South America, Central America, Tropical Asia, and Africa, where the availability of resource...
Source: Mini Reviews in Medicinal Chemistry - July 25, 2023 Category: Chemistry Authors: Anthony Garcia Oliver Grundmann Source Type: research
Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation
CONCLUSIONS: Our experience highlights the importance of conducting a thorough medical history regarding vaccination and serological status of newly immunocompromised patients. Intensive chemotherapy succeeding live vaccine administration <4 weeks could have influenced early and severe viral reactivation. Early initiation of prophylactic antiviral treatment is questioned in such circumstances.PMID:37395442 | DOI:10.1111/petr.14562
Source: Herpes - July 3, 2023 Category: Infectious Diseases Authors: Raad Coralie Chebel Ziad Renaud Christian Teira Pierre Buteau Chantal Tapi éro Bruce Ovetchkine Philippe Source Type: research
A Narrative Review of Alternative Symptomatic Treatments for Herpes Simplex Virus
Viruses. 2023 Jun 2;15(6):1314. doi: 10.3390/v15061314.ABSTRACTHerpes simplex virus-1 (HSV-1) and -2 (HSV-2) are large, spherically shaped, double-stranded DNA viruses that coevolved with Homo sapiens for over 300,000 years, having developed numerous immunoevasive mechanisms to survive the lifetime of their human host. Although in the continued absence of an acceptable prophylactic and therapeutic vaccine, approved pharmacologics (e.g., nucleoside analogs) hold benefit against viral outbreaks, while resistance and toxicity limit their universal application. Against these shortcomings, there is a long history of proven and ...
Source: Herpes - June 28, 2023 Category: Infectious Diseases Authors: Jane Y Chang Curt Balch Joseph Puccio Hyung S Oh Source Type: research
Disseminated vaccine-induced varicella infection in a kidney transplant recipient
Am J Transplant. 2023 Jun 5:S1600-6135(23)00522-1. doi: 10.1016/j.ajt.2023.05.034. Online ahead of print.ABSTRACTA 33-year-old kidney transplant (KT) recipient presented with a disseminated pruritic, painful, vesicular rash and hepatitis three weeks after receiving a varicella vaccine (VAR). A skin lesion biopsy sent to the Centers for Disease Control and Prevention (CDC) for genotyping confirmed vaccine-strain varicella-zoster virus (VZV) (Oka strain; vOka). The patient was successfully treated with intravenous acyclovir during a prolonged hospital stay. This case supports the contraindication of VAR in adult KT recipient...
Source: Herpes - June 7, 2023 Category: Infectious Diseases Authors: Megan A Berman Richard E Rupp Source Type: research
Management of oral herpes simplex virus infections: The problem of resistance. A narrative review
Oral Dis. 2023 Jun 6. doi: 10.1111/odi.14635. Online ahead of print.ABSTRACTHerpes Simplex Virus (HSV) type 1 (HSV-1) and type 2 (HSV-2) are among the most common human viral pathogens, affecting several billion people worldwide. Although in healthy patients clinical signs and symptoms of HSV infection are usually mild and self-limiting, HSV-infections in immunocompromised patients are frequently more aggressive, persistent, and even life-threatening. Acyclovir and its derivatives are the gold standard antiviral drugs for the prevention and treatment of HSV infections. Although the development of acyclovir resistance is a ...
Source: Herpes - June 6, 2023 Category: Infectious Diseases Authors: Evangelia Piperi Erofili Papadopoulou Maria Georgaki Sara Dovrat Mor Bar Illan Nikolaos G Nikitakis Noam Yarom Source Type: research
Combination Therapy for the Treatment of Shingles with an Immunostimulatory Vaccine Virus and Acyclovir
Pharmaceuticals (Basel). 2023 Feb 1;16(2):226. doi: 10.3390/ph16020226.ABSTRACTPractically the entire global population is infected by herpesviruses that establish lifelong latency and can be reactivated. Alpha-herpesviruses, herpes simplex viruses 1 and 2 (HSV-1/HSV-2) and varicella zoster virus (VZV), establish latency in sensory neurons and then reactivate to infect epithelial cells in the mucosa or skin, resulting in a vesicular rash. Licensed antivirals inhibit virus replication, but do not affect latency. On reactivation, VZV causes herpes zoster, also known as shingles. The 76-year-old first author of this paper pub...
Source: Herpes - June 1, 2023 Category: Infectious Diseases Authors: Tibor Bakacs Volker Sandig Imre Kovesdi Source Type: research
A potential anti-HIV-1 compound, Q308, inhibits HSV-2 infection and replication in vitro and in vivo
In this study, we found that Q308 treatment had strong inhibitory activity against both HSV-2 and acyclovir-resistant HSV-2 strains in vitro and reduced the viral titers in tissue. And this treatment effectively ameliorated the cytokine storm and pathohistological changes caused by HSV-2 infection in HSV-2-infected mice. Unlike nucleoside analogs such as acyclovir, Q308 inhibited post-viral entry events by attenuating the synthesis of viral proteins. Furthermore, Q308 treatment blocked HSV-2-induced PI3K/AKT phosphorylation due to its inhibition on viral infection and replication. Overall, Q308 treatment exhibits potent an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2023 Category: Drugs & Pharmacology Authors: Xin Zhang Axin Li Ting Li Zeren Shou Yibin Li Xinman Qiao Ruijing Zhou Xuelin Zhong Songshan Li Lin Li Source Type: research
